You open anything to do with Cannabis while it is still new, you will be Talking about Taxation on Taxation of the taxed taxes. This is how it goes, a clinic opens in A Hood, some municipalities will not approve you if you own the building you intend to do business in. And because you sell Weed, the will claim the cops have to be out a little more in your neighborhood, TAX. Now the cops will need continuous training on some Cannabis related issue, TAX. The city will need to dedicate someone to lok over your shoulder TAX, to show good faith the city "ASKS" you to dedicate a budget to the local rehab, TAX, Keep in mind TAXES go up each year, your commercial lease, because you sell weed will be four times more expensive and instead of the nominal 3% annual increase, your lease will go up by 10%.In addition to the Taxes you will be harpooned with each year, new ones will pop up as time goes by. You even have my fav, the "Obama Said Tax" every time the president says something negative about drugs, a cause comes up that you have to pay for in "Good Faith" for selling drugs here. Now not everything is Tax, some are appropriations by the municipality in exchange for you doing business, selling weed. It is a shakedown. City officials will come in office with a hard on the size of the Capitol full of ways to spend your profits. City officials will come at you so fast, so hard, SO OFTEN THAT by the time they are done Tax-Jack-hammering you without lube, you would have forgotten how it felt to rip one, your Tax Hole will be so stretched, you wont even know when you cut one loose, PHFLEW!