All of a sudden spots appeared

Soil Grow, Happy Frog soil. PH levels all in range, under 24 hr light. Really haven't seen this one before.

Here's a pic, This happened in the last 24 hours

Looks like calcium deficiency. Add some Cal-Mag to the mix to avoid that problem (especially if you are using RO water).

Seems like eaither a serious over-feeding or a serious deficiency.
Over-feeding would be much more common.

Oh... plus a deficiency would show over a much longer period of time.
Did you spray them with anything yesterday? Did you feed them in the last few days?

fed them about three days ago, I will do a more conservative feed next round. If more develops over a time I will supplement some cal-mag to the mix, thanks for the heads up.