Few quick questions about wiring

50v leds running at about 55 watts each. Can I use regular thermostat wire? Also, if I am wiring in parallel, it's a good idea to fuse each led at maybe 1.5a right? Thanks!

How many are you running?

8 cxm22 on 2 hlg-185-48a. They would all be wired separately up to the driver if that matters

On the thermostat wire just check the rated voltage and make sure you're within the limits.

what type of heatsinks are you using

18 ga solid core can handle up to 9.5A http://www.engineeringtoolbox.com/wire-gauges-d_419.html