Well. you're asking the eternal question! The timing is tough when you don't know the maturity time. And it's not just the last 2 weeks of water either, it's the 2 weeks before that for some flavor enhancer, and 2 weeks before that for a PK booster, etc.
That's another reason to grow from cuttings, so you will know the timing.
For a first time growing a strain, you could use the 40/60 Theory. It requires some regular measurement, but it will help you. You measure the growth of the plant through the stretch, and when it slows dramatically, then 40% of ripening time has passed, so you have 60% time left to harvest.
e. g. The plant starts the rapid stretch on day 8 and you measure that she stops growing on day 26. She'll be done approximately day 65.
HTH