Oh yea. I have done this a few times if you care to read my cabinet journals links below.
The lower stuff really is not worth keeping. By removing it you achieve three things, one is the plant will now send all its available nutrients to the upper branches where it can do the most good and second, you now can curculate the co2 from the bottom of the cab to the top and the bonus is you have a bunch of cuttings you can clone. My favorite part.
I cut the lower stuff and add fans, take the cutting and start them rooting. Wait a week then top each one, wait another week and flip to 12/12 at that point any lower stuff I cant train to get some light I would remove. Then you done, let the buds grow while you veg the next round.