Opiate Potentiates?

I'm curious to know some ways in which people like to potentiate opiates.

I've known many people who use benzos like valium and xanax to great effect.

I've also heard of OTC sleeping pills/benedryl (diphenhydramine) being used and even DXM is supposedly used to potentiate the effects of opiates.

The reasons for potentiating opiates is obvious, I'm just curious as to whether or not the serious opiate users on this forum potentiate their stuff or use it alone. If so whats your favorite/most effective way and why?

As the resident junky, I prefer benedryl or white grapefruit juice. It works just as well as Benzos but is far less lethal, especially when IVing. I don't smoke weed but that is another very effective potentiator. Hash brownies give the closest high to narcotics, are cheaper, and as safe as white grapefruit juice.

potentiate, is that really a word? like to make more potent?

to stay on topic....

back in the day i used to mix a perk an OC20 and a k-pin, toss em all in the pill crusher and do em all at once, that was a weird kind of fucked up

The only thing i like mixing with Benzos is speed. Xanax+Ritalin= pharmaspeedball. Weed+coffee= hippie speedball. Oxycontin+MS Contin is another very enjoyable cocktail. We were also doing "Death Rides" which are a mixture of cocaine+nice clean crystal+Fentanyl soaked Oxycontin.
It was terrifyingly enjoyable.

death rides? are you a hells angel?

while i stayed away from the stronger side i quite often do a CWE on codeine or dyhydrocodeine i bought a some codiene bout an hour ago to do tonight
i always buy a carton of grapefruit juice to drink before hand benedrill works quite well too
then i have some beers and the codeine its nice i get pretty toasted but i wouldnt recomend doing this very often tho

What does the grapefruit juice do?

victozap said:

What does the grapefruit juice do?

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im not a scientist but they way i understand it grapefruit juice inhibits an enzyme CYP3A4. this enzyme works as a natural buffer against drugs taken orally so a galss of grapefruit juice taken up to 24 hours before hand will increase the amount of the drug that your body absorbs. so with codeine it makes the same amount you take up to 50% stronger (you absorb more of the same amount taken)

i think thats the jist of it. just be carefull when trying it and always check you normal prescriptions before drinking grapefruit juice with them

.Calico said:

As the resident junky, I prefer benedryl or white grapefruit juice. It works just as well as Benzos but is far less lethal, especially when IVing. I don't smoke weed but that is another very effective potentiator. Hash brownies give the closest high to narcotics, are cheaper, and as safe as white grapefruit juice.

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Yeah, I've used xanax and valiums before and they really do the trick but you're right, the margin of safety really seems to decrease. Benedryl seems like a good bet because it is legal, cheap and always avalible. Do you just pop or chew up a few of them before you shoot up?

How much more faded do you actually feel?

Does white grapefruit juice have more effective properties then regular pink kind?

Oh wow, I never knew that. So say you drank it with Benedryl, would it be the same 50% or is it different with every drug?

victozap said:

Oh wow, I never knew that. So say you drank it with Benedryl, would it be the same 50% or is it different with every drug?

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yeah it helps altho i couldnt put a figure on it benedryl (Diphenhydramine) inhibits CYP2D6 one of the enzymes used by the liver to break codeine down into the good stuff you want. i think it allows more of it to be turned into morphine.

if you are thinking about trying this then start low dont go rushing in and take too much opiates arent very forgiving

Opiates and DXM could be deadly. FYI.

thehairyllama said:

Opiates and DXM could be deadly. FYI.

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opiates on their own can be deadly fuck even if it dont kill you if you get addicted you'l wish it had.
i never tried codeine with dextrometophan (dxm) though as we can only get it in bottles of cough mixture robbotisun or what ever its called.
we get diphenhydramine in pure form in sleeping tablets tho much easier than chugging syrupy crap

Saying the mix is deadly douche.
Any substance can kill you. Some mixed together can do it a lot faster or instantly. =D. I posted some DXM facts about what not to take it with but yeah.

DXM should never be taken while on medications such as MAOIs and SSRIs, this may interact with DXM to cause serotonin syndrome. This condition, although rarely fatal, is not terribly pleasant. Some of the symptoms of serotonin syndrome include muscle rigidity, confusion, diarrhea, incoordination, low-grade fever, sweating, muscle tremor, mania, agitation, exaggerated reflexes, and nausea. Some drugs to avoid taking while on DXM are:

• phentermine, fenfluramine, phen-fen (diet drugs)

• fluoxetine (Prozac®, an SSRI), tricyclics and lithium (antidepressants)

• terfenadine (SeldaneTM - prescription antihistamine), & possibly other non-drowsy antihistamines, such as ClaritinTM and HisminalTM (these can cause heart irregularities)

• antidepressants Desyrel (trazodone) & Serzone (nefazodone) (Possible liver damage)

• some SSRIs such as bupropion (WellbutrinTM) can give a prolonged (3+ day) hangover.

• also, cigarette smoke might be considered an MAOI, which may increase unwanted side-effects

• MDMA (extacy), while it isn't a MAOI, it should be avoided with DXM (possible heart problems)

• opiates and cocaine can cause a fatal overdose when mixed with DXM.
Just figured id throw it up there again for the occasion. No clue were I posted it before.

thehairyllama said:

Saying the mix is deadly douche.

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deadly douche? i wouldnt want to meet one of them down a dark alley lol dont mind me man its very late/early in the morning i aint got hash and im not with it. i wanna reefer so i can start thinking straight again im far to dangerous to myself like this

Haha its cool. Ill Pass the pipe your way =D.

thehairyllama said:

Saying the mix is deadly douche.
Any substance can kill you. Some mixed together can do it a lot faster or instantly. =D. I posted some DXM facts about what not to take it with but yeah.

DXM should never be taken while on medications such as MAOIs and SSRIs, this may interact with DXM to cause serotonin syndrome. This condition, although rarely fatal, is not terribly pleasant. Some of the symptoms of serotonin syndrome include muscle rigidity, confusion, diarrhea, incoordination, low-grade fever, sweating, muscle tremor, mania, agitation, exaggerated reflexes, and nausea. Some drugs to avoid taking while on DXM are:

• phentermine, fenfluramine, phen-fen (diet drugs)

• fluoxetine (Prozac®, an SSRI), tricyclics and lithium (antidepressants)

• terfenadine (SeldaneTM - prescription antihistamine), & possibly other non-drowsy antihistamines, such as ClaritinTM and HisminalTM (these can cause heart irregularities)

• antidepressants Desyrel (trazodone) & Serzone (nefazodone) (Possible liver damage)

• some SSRIs such as bupropion (WellbutrinTM) can give a prolonged (3+ day) hangover.

• also, cigarette smoke might be considered an MAOI, which may increase unwanted side-effects

• MDMA (extacy), while it isn't a MAOI, it should be avoided with DXM (possible heart problems)

• opiates and cocaine can cause a fatal overdose when mixed with DXM.
Just figured id throw it up there again for the occasion. No clue were I posted it before.

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I've heard of people taking dxm to boost the effects of their opiates. I imagine you'd just have to be careful and start small when mixing with benzos, benedryl or strong opiates in general.

Anyone personally tried it?

Personally, I eat my benedryl although i have seen it mixed with h, cooked, and shot. H on its' own requires about 1cc of H2O. If you plan on booting 2 benedryl along with your opi's, you're gonna need a bigger fit. Something along the lines of a 3ml. I find when i am IVing opiates, a potentiator is the last thing i need! As far as the grapefruit juice goes, I've always been told to drink the white so I drink the white. However, I have drank the pink grapefruit juice along with my E with increased effects.

Keep in mind that anything that decreases your ability to metabolize opiates can increase your likelyhood of od'ing, even grapefruit juice. Try out the WGFJ and benedryl on thier own at first. Then practice cocktailing.

i find that when i take benzos along with my ocaisional methadone or heroin dose it definately multiplies the effects. much more so than either one on its own. guaranteed nods! very dangerous though. it will kill less the less experienced.

.Calico said:

H on its' own requires about 1cc of H2O.

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only 1cc? i usualy use about 15-20cc's per shot.