I've done it, but it depends on how far into flowering you are. The later, the worse results with clones. Getting them to root, and veg again seems to take more time the deeper into flowering you are. I've done up to five weeks into flowering, with poor results.
As for your yield, you don't need very large clones, ( I always take them from the bottom branches that don't flower well anyway ) and you won't stress the plant if you don't cut much.