Looks to me like it could be overwater, nitrogen deficiency or overfert, or the pH is off, but really if you said the pH might be off for every person asking a question on here you wouldn't be wrong...the pH being wrong or fluctuating rapidly can cause every symptom you can think of just about...lol.
So, what lights do you have? What soil are you using? And have you given them any nutes? If so, how much of what kind with how much water how often...? If not>>>then they need some...
How old are they...I see what looks like flowering..so is this plant in flowering? The leaves don't look too terrible to be totally honest...and sometimes in flower the lower leaves will die off, and I see that your cotyledons are still there and visible, so you really haven't lost too many leaves...but you say it is killing higher up leaves as well?
some pictures of the whole plant would help me out a lot to tell the truth...I know it is annoying to take pics of flowering plants but for real get them somewhere with a more natural light spectrum and let's see what is going on here...I know how this feels, seeing something happening and perhaps what you have tried is not helping or you just have no idea what it could be...
I might not know either, but there is a better chance that I might if you show me some correct colored pics of the whole plant...ooohh and answer the litany of above questions...medium, lights, water? the basics...