So now I get to reverse myself - OF course extract if you can but... the 325's aren't bad, the threshold for bad alcohol mixing is 1.5 grams or so. I am given to understand that the acet waits in line until all the alcohol is metabolized - now be advised that could be bulshit.
The folks that really endanger their livers are the ones who take the 5/500's. They will take 4 or 6 of them and then start in on beer and the like, that is 2 - 3 GRAMS of acet. And then they usually continue to hook them down. This stuff isn't good for you when mixed with alcohol at all, but you can get away with drinking at the 325 level. By the way I am given to believe that a new law takes effect next year that will make all of these sorts of compounds illegal, in other words, no acet in any opiate product. (they might, however replace it with aspirin, if so, now you are going to have stomach bleeding instead of risking your liver - how nice)