Just tried edibles

coreywebster said:

Interesting.

I make gummies that destroy most of the hard-core tokers who've been smoking years and yet every so often don't touch the odd person that has a normally low tolerance.

Like one guy who's got high tolerance can have 1 gummy at 10mg and be ruined all night and another guy can neck the whole 200mg pack and not feel a thing.

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Short into to First Pass Effect:

Then it's CYP450 and finally binding at the endocannabinoid system's receptor sites. Usually all these studies are done by a drug manufacturer so we know. However with cannabis we haven't been allowed to study it so here we are.

curious2garden said:

Short into to First Pass Effect:

First-Pass Effect - StatPearls - NCBI Bookshelf

Then it's CYP450 and finally binding at the endocannabinoid system's receptor sites. Usually all these studies are done by a drug manufacturer so we know. However with cannabis we haven't been allowed to study it so here we are.

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Bro science is about all we have, but that's more than nearly all doctors have put together. I would like to see a bro science section here. Everyone post what they have tried and what the results were. Just as an example I use m for my arthritis and last weeI I used Chocolope to make my coconut oil instead of the Critical Mass I normally use. My blood pressure went out of sight and it didn't do my arthritis as well. What would a new user think, that it does bad things? If there's a bro science page that new user could look there and see what works and what doesn't.

I didn't mean to get so wordy but I just finished making 4 dozen peanutbutter cookies and had to make room in the cookie jar them.

DancesWithWeeds said:

Bro science is about all we have, but that's more than nearly all doctors have put together. I would like to see a bro science section here. Everyone post what they have tried and what the results were. Just as an example I use m for my arthritis and last weeI I used Chocolope to make my coconut oil instead of the Critical Mass I normally use. My blood pressure went out of sight and it didn't do my arthritis as well. What would a new user think, that it does bad things? If there's a bro science page that new user could look there and see what works and what doesn't.

I didn't mean to get so wordy but I just finished making 4 dozen peanutbutter cookies and had to make room in the cookie jar them.

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Doctors have a head start because of all the science, math, biology, chemistry and physics et cetera that you have to take to get there. Then you add pharmacology and that certain chemicals behave in a predictable manner in vivo and you can generalize and extrapolate to some degree. That's how you come up with a hypothesis that you then test. So I'd still bet that most MDs are a little further ahead than most broscience practitioners but still a shame it's a Schedule 1 drug, sad.

About your blood pressure, I've found that certain cannabis strains (usually what we colloquilly refer to as 'sativa'), have an alpha 1 agonist affect. I found it particularly strong in C99, and a few others. For example a common antihistamine, phenylephrine is also used as a pressor agent. You've probably taken that if you've had a cold. Does this cannabis feel similar to that.

So government excuses are of their own making, Big surprise. 70-80 % want it but Big Daddy is stepping his dick.

curious2garden said:

Doctors have a head start because of all the science, math, biology, chemistry and physics et cetera that you have to take to get there. Then you add pharmacology and that certain chemicals behave in a predictable manner in vivo and you can generalize and extrapolate to some degree. That's how you come up with a hypothesis that you then test. So I'd still bet that most MDs are a little further ahead than most broscience practitioners but still a shame it's a Schedule 1 drug, sad.

About your blood pressure, I've found that certain cannabis strains (usually what we colloquilly refer to as 'sativa'), have an alpha 1 agonist affect. I found it particularly strong in C99, and a few others. For example a common antihistamine, phenylephrine is also used as a pressor agent. You've probably taken that if you've had a cold. Does this cannabis feel similar to that.

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The trouble with doctors is that they are given a list of "opinions" that are mostly backed by closed minded people with some kind of authority. Most of it based on lies from the past or big money. My "ex-cartioligst" was giving me all that bs about it taking years to "test" each cananoid. I told him I don't have years to wait on them and at 83 yo I'm not worried about long term effects. He got mad and stomped out of the room and I fired him on the spot.

I did make peace with my regular doctor. He made the comment "I don't know why you haven't stroked out already". He is starting to believe me now about how I drop BP. It works for me but maybe not for anyone else. The sad thing is that he closed minded about MJ. He said, "I don't want to hear about any of your success stories." Actually, th MJ is for arthritis but I have to fit in in BP so I make it work. He has seen my BP drop from >200 to less than 120 in 2 hours several times but doesn't except reality.

I get most of my better information from Israel. I read the abstract on every MJ medical jurnal on line that comes from Israel. About the best you can get from the US is "more research needs to be done."

DancesWithWeeds said:

The trouble with doctors is that they are given a list of "opinions" that are mostly backed by closed minded people with some kind of authority. Most of it based on lies from the past or big money. My "ex-cartioligst" was giving me all that bs about it taking years to "test" each cananoid. I told him I don't have years to wait on them and at 83 yo I'm not worried about long term effects. He got mad and stomped out of the room and I fired him on the spot.

I did make peace with my regular doctor. He made the comment "I don't know why you haven't stroked out already". He is starting to believe me now about how I drop BP. It works for me but maybe not for anyone else. The sad thing is that he closed minded about MJ. He said, "I don't want to hear about any of your success stories." Actually, th MJ is for arthritis but I have to fit in in BP so I make it work. He has seen my BP drop from >200 to less than 120 in 2 hours several times but doesn't except reality.

I get most of my better information from Israel. I read the abstract on every MJ medical jurnal on line that comes from Israel. About the best you can get from the US is "more research needs to be done."

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that kind of doctor is a "cardiologist" not cartiologist. He isn't making maps. The other one is "don't confuse me with the facts my mind is made up".
I am really starting to despise doctors. But then I'm in the law biz. Doctors hate us because we are not influenced by "I'm a God/Doctor".

grayeyes said:

that kind of doctor is a "cardiologist" not cartiologist. He isn't making maps. The other one is "don't confuse me with the facts my mind is made up".
I am really starting to despise doctors. But then I'm in the law biz. Doctors hate us because we are not influenced by "I'm a God/Doctor".

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You should know about spell checkers and stoned people by now. They have some good clips on YouTube. Take a look. You'll LYAO! (In caps).

DancesWithWeeds said:

Bro science is about all we have, but that's more than nearly all doctors have put together. I would like to see a bro science section here. Everyone post what they have tried and what the results were. Just as an example I use m for my arthritis and last weeI I used Chocolope to make my coconut oil instead of the Critical Mass I normally use. My blood pressure went out of sight and it didn't do my arthritis as well. What would a new user think, that it does bad things? If there's a bro science page that new user could look there and see what works and what doesn't.

I didn't mean to get so wordy but I just finished making 4 dozen peanutbutter cookies and had to make room in the cookie jar them.

Click to expand...

Im a believer in the power of terpenes and all the other cannabinoids in different strains of weed. Since ive finally got consistent indica genetics, im able to take advantage of paranoia-less couchlock. The GG4 will couchlock me, but at a price of being waay too high. My blood pressure jumps on sativa dominant strains too. Especially if i eat it. I havent tried eating the kush yet. I got 4 grams of super sticky trim i now see a clear purpose for. To Bro Science!

CarolinaPothead said:

Im a believer in the power of terpenes and all the other cannabinoids in different strains of weed. Since ive finally got consistent indica genetics, im able to take advantage of paranoia-less couchlock. The GG4 will couchlock me, but at a price of being waay too high. My blood pressure jumps on sativa dominant strains too. Especially if i eat it. I havent tried eating the kush yet. I got 4 grams of super sticky trim i now see a clear purpose for. To Bro Science!

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You know that everyone reacts differently with pot. Unfortunately sativa makes mine hit the roof. I get major couchlock from Critical Mass but at least for me it does a good job dropping my BP IF I eat it. I don't think smoking it will lower mine at all. I've tried it and it always goes up. On the other hand edibles from CM or Big Bud almost always brings it down for me.

Somewhere I have a link to a New York Times about an Israel doctor found that pot can lower BP in people over 60. I fairly sure I know where it is but if I go looking I'll probably lose this post and have to do it again.

Critical mass is one of my wanna grow strains. Im a big skunk fan and i love afghani too. Ive got 2 afghan kush going right now. CM just seems like it should tick the boxes i like. What breeder do you use?

DancesWithWeeds said:

The trouble with doctors is that they are given a list of "opinions" that are mostly backed by closed minded people with some kind of authority.

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Oh, i dunno about all this, "i'm smarter than a doctor" bit. Who's finished a bachelor's degree? Who's finished one in pre-medicine?
How about med school? Internship? Residency? I dunno, i did a BA degree in lib arts, NOT science or medicine, it was a bitch. I could never
do a MD course. Takes like 9 years from freshman year to finish. Who has done that? I think de-emphasizing the level of training and education that goes into medicine is wrong-headed. Sure they, like all humans, need oversight and review, for damn sure, and most practitioners undergo that process for their entire careers. But to say somebody who's stuck seeds in the soil for 10 or 20 years is more skilled than your average MD is seriously over estimating their own prowess. I went to school with pre-med kids, they were carrying double a full load, working constantly, taking every hard core science class the university had to offer. I'd get high with this one guy, he'd have like 15 minutes, and then off to class. That boy and others who i knew were busy as hell, ALL THE TIME. So, i got more respect for them maybe than they deserve, but i can't downplay the rigor they had to extend to finish their degrees.

doughper said:

Oh, i dunno about all this, "i'm smarter than a doctor" bit. Who's finished a bachelor's degree? Who's finished one in pre-medicine?
How about med school? Internship? Residency? I dunno, i did a BA degree in lib arts, NOT science or medicine, it was a bitch. I could never
do a MD course. Takes like 9 years from freshman year to finish. Who has done that? I think de-emphasizing the level of training and education that goes into medicine is wrong-headed. Sure they, like all humans, need oversight and review, for damn sure, and most practitioners undergo that process for their entire careers. But to say somebody who's stuck seeds in the soil for 10 or 20 years is more skilled than your average MD is seriously over estimating their own prowess. I went to school with pre-med kids, they were carrying double a full load, working constantly, taking every hard core science class the university had to offer. I'd get high with this one guy, he'd have like 15 minutes, and then off to class. That boy and others who i knew were busy as hell, ALL THE TIME. So, i got more respect for them maybe than they deserve, but i can't downplay the rigor they had to extend to finish their degrees.

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Hello

Welll, i got my Bachelors in Electronics Engineering technology and all it taught me about weed was that i needed to smoke some to sleep during the few hours i had between classes and labs. Doing pre-med? Fagettaboutit! They have a crazy courseload intended to either forge a doctor or make a mf'er drop out. But not much is taught about cannabis. Sure they take toxicology and pharmacology classes but they generally dont have time for horticulture. I used to sell a fair amount of weed and shrooms 30 years ago to med students and they are sometimes so smart but so dingy. Lol. No , I don't think myself smarter than a MD but when bossman needs electronic shit done i get called alot i guess im saying that if i am sick i go see a Dr. , but when i want to know what the hell is wrong with my crop i ask @Budzbuddha. lol. Weed does need to be given the proper research funding that would help clear up alot of the mysteries. I believe cannabis possesses the potential to be truly transformational pharmacologically. I have personally seen and felt the medicinal power of cannabis as well as benefited from its recreational relaxative effects. Just like i know this OG Kush makes me chatty else i woulda got tired of talking paragraphs ago. I forgot where i was going with this,, oh yeah, @DancesWithWeeds, i cooked and ate it in pudding earlier. Youre right, its definitely different . Almost an opioid feel. Way different from the GG4.

CarolinaPothead said:

Bachelors in Electronics Engineering technology

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Sheeit, man, talk about a rigorous course. After awhile, i got used to these freshmen/sophomores, saying
"i'm gettin' my EE degree." Next semester, I'd be, "how's that EE course going?"
"I changed my major to ME (mech engineering)". Then a semester or so later, "I changed again to CE (Civil).'
I knew some EE guys, super brainy, super smart. Yup, college back then had some tough majors, I would
hope nothing's changed.

DancesWithWeeds said:

About the best you can get from the US is "more research needs to be done."

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I need to make sure Weeds here doesn't think i'm pickin' on him. I kind of read that wrong, and went off on my little
tangent, pet peeve about people who think they know more than experts, especially with the advent of the www. And Weeds
here, is absolutely correct in saying that research is not allowed on cannabis due to ... well, racisim, i suppose, because why
else is it so stigmatized in USA that research on the substance isn't even allowed? Weeds is dead right. Israel huh? Hmm.

doughper said:

Sheeit, man, talk about a rigorous course. After awhile, i got used to these freshmen/sophomores, saying
"i'm gettin' my EE degree." Next semester, I'd be, "how's that EE course going?"
"I changed my major to ME (mech engineering)". Then a semester or so later, "I changed again to CE (Civil).'
I knew some EE guys, super brainy, super smart. Yup, college back then had some tough majors, I would
hope nothing's changed.

I need to make sure Weeds here doesn't think i'm pickin' on him. I kind of read that wrong, and went off on my little
tangent, pet peeve about people who think they know more than experts, especially with the advent of the www. And Weeds
here, is absolutely correct in saying that research is not allowed on cannabis due to ... well, racisim, i suppose, because why
else is it so stigmatized in USA that research on the substance isn't even allowed? Weeds is dead right. Israel huh? Hmm.

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There are serveral reasons they don't research pot here. First, follow the money. The really bad thing is it's against the law for legitimate research to be done without a lot of bs that doesn't have to happen. At any rate there are so many variables that the odds of them stumbling on something that works is a little slim.

Some time back, maybe a couple of years, UCLA spent how much money finding out that if you smoke standing and then sit down your blood pressure will go up. Why didn't they just a few smokers. Compare that kind of "research" with what's going on in Israel. I don't pay to read the the whole thing but I do read the abstract on every Israeli pot test I see.

DancesWithWeeds said:

I do read the abstract on every Israeli pot test I see.

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TY for the info. I'll check out Israeli research and abstracts for sure.

When you sit at home and think an edible is kinda kicking getting you high, go out and try to grocery shop or order food at a joint. It’s amazing how different the chill affect at home is compared to the affect when trying to function in society.

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The high ratio of Lecithin is the Key to the Lock your missing.

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Mango juice can sure help.

doughper said:

TY for the info. I'll check out Israeli research and abstracts for sure.

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Try looking up "evidence based medical marijuana research israel". They have been researching it, to some extent, since 1960, and it's encouraged by the government, not outlawed. Follow the links and there will be more than you can read. You may have to go to Google Scholar to find it.

My wife and I used to get waaay high from edibles. Recently, she had her gallbladder removed and since then, they don’t do a thing to her (still work on me though).