Pandemic 2020

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DIY-HP-LED

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The Race to Get Convalescent Plasma to Covid-19 Patients
Blood centers across the nation are trying to get antibodies from coronavirus survivors to patients who want this experimental treatment. But it’s not easy.

ONE MORNING A few weeks ago, Rebecca Haley realized that her job had changed. Haley is the medical director for blood collection at Bloodworks Northwest, a nonprofit that serves 90 hospitals in the Pacific Northwest. But, Haley decided, regular blood and platelet donations weren’t the focus anymore. Like thousands of blood centers across the country, Bloodworks needed to collect something new: plasma from Covid-19 survivors.

Once someone is infected with the virus that causes Covid-19, their immune system begins to produce antibodies, specialized cell protectors that recognize the new coronavirus and fend it off. Once that person has recovered, their blood retains the antibodies. Transfusing those antibodies into a Covid-19 patient might be able to help them fend off their own infection, buying them time until their immune system starts producing its own antibodies. This treatment is known as convalescent plasma therapy, and it’s an old solution; doctors used it to help treat measles patients before a vaccine was developed and it has been used on Ebola, SARS, and MERS patients, as well as during the 1918 pandemic flu.

Scientists don’t know yet if this strategy works against Covid-19, but in early April the Food and Drug Administration approved two nationwide clinical trials that the agency would coordinate. As those trials get underway, blood centers around the country are mounting an unprecedented effort to collect the potentially life-saving substance—but they are also facing thorny logistical and ethical problems along the way.

“Nearly every blood center in the country has mobilized to help collect convalescent plasma,” says Kate Fry, CEO of America’s Blood Centers, a national network of 600 such centers. She says tens of thousands of people have reached out wanting to donate. “Thousands of units have already been shipped. We’re hoping for tens of thousands in the coming months,” she adds.

One of the upsides to trying convalescent plasma as a therapy is that it’s readily available from all those donors, and can be given to a patient as soon as 36 hours after being collected. But there are still many practical unknowns when it comes to using it for Covid-19. Should it be used only to help very sick patients, or should it be administered earlier in the course of the infection, before patients need to be put on a ventilator? How much do people need?

Researchers are running clinical trials to answer those questions, but the consensus right now is that, at the very least, convalescent plasma doesn’t seem to do much harm. With no proven treatments available for Covid-19, the FDA loosened restrictions on who can use the experimental therapy, allowing hospitals to join clinical trials or to use it in “compassionate use” cases, which are allowed for critically ill people when no other treatment options exist.
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DIY-HP-LED

Well-Known Member

Preliminary results from a remdesivir trial could come in a week or two, researcher says

(CNN)Preliminary results from a clinical trial of remdesivir, an experimental antiviral drug being tested for coronavirus, could come in as little as one to two weeks, a top researcher said Sunday.
The final results aren't expected until mid-to-late May, said Dr. Andre Kalil, a principal investigator for the trial. But he said "we can potentially have some early data in the next one or two weeks," contingent on a preliminary analysis.
"In the next few weeks, we're going to do the analysis, and we're going to basically know if remdesivir is better or not than placebo," he told CNN.
Remdesivir was originally tested by Gilead Sciences as a potential treatment for Ebola, and it showed activity against the novel coronavirus in test tubes. But whether the drug is an effective treatment for Covid-19 remains unclear, and data released thus far have been conflicting and limited.


NIH Covid-19 treatment guidelines warn against drug combo pushed by Trump

NIH Covid-19 treatment guidelines warn against drug combo pushed by Trump


The new study, sponsored by the National Institutes of Health, is a randomized, double-blind, placebo-controlled trial. That means it compares patients who received remdesivir with those who didn't, and neither the patients nor the doctors treating them know who is receiving the real drug and who is receiving a placebo.
That helps protect against bias and makes the study results more believable, and the design is thought to be the gold standard for clinical research.
Enrollment for the study was completed last Sunday, Kalil said, adding that "we enrolled more people than we actually predicted." He was unable to say how many patients total were in the trial, but said it was more than the 572 participants listed as a target.
Reuters reported on Friday that the study was running ahead of schedule, with results potentially coming soon.

Study includes patients from around the world
The trial began at the University of Nebraska Medical Center, where Kalil is a professor of medicine, but it has since expanded to nearly 70 sites around the world, from South Korea to Germany.
Remdesivir trial posted online prematurely was 'inconclusive,' Gilead says

Remdesivir trial posted online prematurely was 'inconclusive,' Gilead says


Kalil said he wants to see results that show "meaningful clinical benefits" for patients. "We want to see something that really matters, something that really changed the outcomes of these patients," he said. The idea "is not just feeling a little bit better," such as a minor shortening of fever.
While the hope is that patients' infections will resolve more quickly on remdesivir, Kalil said he wouldn't speculate on the outcome of the trial. "This is not a time to guess, this is a time to really get the data," he said.
"If the drug works, great. If the drug doesn't work, we can remove the drug from the trial and try other therapies."

Leaked data and early results paint a confusing picture
The data on remdesivir are confusing at best. Earlier this month, the maker of the drug, Gilead, released information on 53 patients, the majority of whom showed clinical improvement after receiving infusions of remdesivir.
While Gilead called that data "encouraging," the study had no control group, making it difficult to know whether remdesivir actually helped the patients more than supportive care, the current standard.
Information leaked to STAT News also suggested that coronavirus patients receiving remdesivir in a clinical trial were recovering quickly. But STAT's report was based on a recorded discussion of the trial, and it offered few details.
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Last week, the World Health Organization accidentally published a summary of results from a clinical trial of the drug in patients with severe Covid-19. A screenshot of the summary published by STAT showed "remdesivir use was not associated with a difference in time to clinical improvement."
But that trial was terminated early due to low enrollment, and Gilead said the results were posted prematurely. The study was inconclusive, the company said, and "the post included inappropriate characterizations of the study."
 

Jimdamick

Well-Known Member
Two months ago today someone that you know very well made these comments.

“Thirty-five thousand people on average die each year from the flu. Did anyone know that?”

“Thirty-five thousand, that’s a lot of people. It could go to 100,000. It could be 20,000. They say usually a minimum of 27, goes up to 100,000 people a year die — and so far we have lost nobody to coronavirus in the United States.”

“Nobody,”

Death toll today so far as I type this is 58, 946, with over 10,000 dead within 70 miles of where I live

“And it doesn’t mean we won’t, and we are totally prepared. It doesn’t mean we won’t. But think of it, you hear 35 and 40,000 people, and we’ve lost nobody. You wonder if the press is in hysteria mode.”

At a continued rate of mortality by the end of this week, we will have lost more lives than the entire Vietnam war, in 4 months.
https://theintercept.com/2020/04/27/in-just-months-the-coronavirus-kills-more-americans-than-20-years-of-war-in-vietnam/

Trump today said he plans to declare meat plants as a critical infrastructure, and cite the Defense Production Act to justify an order to keep them open, said two officials familiar with the discussions, speaking on condition of anonymity because the order is not yet completed. The officials said Trump could sign the order today

Earlier, Trump had said he did not fear any kind of food shortage.

Trump also said today that he would issue an executive order to shield meat plants from legal liability if they are sued by employees who contract coronavirus while on the job.

While Trump only mentioned Tyson Foods specifically, he suggested his order would protect other businesses from liability as well.

What the fuck can anyone say, besides just hope & pray your alive & heathy enough to go vote in November and end this nightmare of presidency.
 
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Fogdog

Well-Known Member
Two months ago today someone that you know very well made these comments.

“Thirty-five thousand people on average die each year from the flu. Did anyone know that?”

“Thirty-five thousand, that’s a lot of people. It could go to 100,000. It could be 20,000. They say usually a minimum of 27, goes up to 100,000 people a year die — and so far we have lost nobody to coronavirus in the United States.”

“Nobody,”

Death toll today so far as I type this is 58, 946, with over 10,000 dead within 70 miles of where I live

“And it doesn’t mean we won’t, and we are totally prepared. It doesn’t mean we won’t. But think of it, you hear 35 and 40,000 people, and we’ve lost nobody. You wonder if the press is in hysteria mode.”

At a continued rate of mortality by the end of this week, we will have lost more lives than the entire Vietnam war, in 4 months.
https://theintercept.com/2020/04/27/in-just-months-the-coronavirus-kills-more-americans-than-20-years-of-war-in-vietnam/

Trump today said he plans to declare meat plants as a critical infrastructure, and cite the Defense Production Act to justify an order to keep them open, said two officials familiar with the discussions, speaking on condition of anonymity because the order is not yet completed. The officials said Trump could sign the order today

Earlier, Trump had said he did not fear any kind of food shortage.

Trump also said he would issue an executive order to shield meat plants from legal liability if they are sued by employees who contract coronavirus while on the job.

While Trump only mentioned Tyson Foods specifically, he suggested his order would protect other businesses from liability as well.

What the fuck can anyone say, besides just hope & pray your alive & heathy enough to go vote in November and end this nightmare of presidency.
About the only printable response I could make to all that is to observe that landlords excel at dishing risk onto tenants while they collect the rewards.

"Head I win, tails you lose"
 

topcat

Well-Known Member
Two months ago today someone that you know very well made these comments.

“Thirty-five thousand people on average die each year from the flu. Did anyone know that?”

“Thirty-five thousand, that’s a lot of people. It could go to 100,000. It could be 20,000. They say usually a minimum of 27, goes up to 100,000 people a year die — and so far we have lost nobody to coronavirus in the United States.”

“Nobody,”

Death toll today so far as I type this is 58, 946, with over 10,000 dead within 70 miles of where I live

“And it doesn’t mean we won’t, and we are totally prepared. It doesn’t mean we won’t. But think of it, you hear 35 and 40,000 people, and we’ve lost nobody. You wonder if the press is in hysteria mode.”

At a continued rate of mortality by the end of this week, we will have lost more lives than the entire Vietnam war, in 4 months.
https://theintercept.com/2020/04/27/in-just-months-the-coronavirus-kills-more-americans-than-20-years-of-war-in-vietnam/

Trump today said he plans to declare meat plants as a critical infrastructure, and cite the Defense Production Act to justify an order to keep them open, said two officials familiar with the discussions, speaking on condition of anonymity because the order is not yet completed. The officials said Trump could sign the order today

Earlier, Trump had said he did not fear any kind of food shortage.

Trump also said he would issue an executive order to shield meat plants from legal liability if they are sued by employees who contract coronavirus while on the job.

While Trump only mentioned Tyson Foods specifically, he suggested his order would protect other businesses from liability as well.

What the fuck can anyone say, besides just hope & pray your alive & heathy enough to go vote in November and end this nightmare of presidency.
Trumpy now tries to spin it as how many he's saved, if he had "done nothing", instead, giving ever higher numbers, up to billions. This, after he said we had it in "total control" and "soon, it will be down to zero". He relies on vague shouts of "if I hadn't shut it down", the reference being flights of nationals from China, conveniently neglecting to note 40,000 Americans and legal residents coming back that could only be presumed a percentage of were infected. Weak sauce, but a conman knows his crowd and reacts to their anger and fear, stoking the fires, and selling snake oil. "Ivanka's cure all elixir" will get a trademark.
 
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Jimdamick

Well-Known Member
Trumpy now tries to spin it as how many he's saved, if he had "done nothing", instead, giving ever higher numbers, up to billions. This, after he said we had it in "total control" and "soon, it will be down to zero". He relies on vague shouts of "if I hadn't shut it down", the reference being flights of nationals from China, conveniently neglecting to note 40,000 Americans and legal residents coming back that could only be presumed a percentage of were infected. Weak sauce, but a conman knows his crowd and reacts to their anger and fear, stoking the fires, and selling snake oil. "Ivanka's cure all elixir" will get a trademark.
What really now makes me laugh/cry is that motherfucker & the GOP in general are trying too pin his ineptitude on the Chinese/Dems/W.H.O.
He NEVER FUCKING EVER admits a mistake, even when the facts are there, in print or in video, right in front of his/our eyes.
Vote every fucking Republican out of office this next election & start over, or we're truly fucked, but I think it's too late actually
 

topcat

Well-Known Member
What really now makes me laugh/cry is that motherfucker & the GOP in general are trying too pin his ineptitude on the Chinese/Dems/W.H.O.
He NEVER FUCKING EVER admits a mistake, even when the facts are there, in print or in video, right in front of his/our eyes.
Vote every fucking Republican out of office this next election & start over, or we're truly fucked, but I think it's too late actually
In the old west, he'd have been tar and feathered, or run out on a rail, if he wasn't hanged for swindling hard working people's money. It's classic flimflam, complete with the hand motions. Old as dirt.
 

DIY-HP-LED

Well-Known Member
A shoot out at the OK corral between G men and the house Sergeant of Arms! MAGA! Are ya tired of winning yet? Arrest Bill Barr and build a fucking dungeon in the basement of the house, dig deeper if ya need the extra room! Have him appear in cuffs wearing a canary yellow jumpsuit, sing on the hot seat or rot in jail Billy! The Sergeant at Arms might hire a couple of hundred retired FBI agents and deputise them for some inherent powers of congress work of an arresting nature.
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Judges worry Trump position on McGahn testimony could force Congress into extreme measures
The fight centers on one of the most urgent political and legal issues of Trump’s presidency.

Barring Congress from enforcing its subpoenas in court could push lawmakers toward arresting senior Trump administration officials or pursuing even more extreme measures, several appeals court judges suggested Tuesday.

It was the second time in recent months that the D.C. Circuit Court of Appeals has openly mulled the bizarre and unnerving prospect of armed conflict between the House sergeant-at-arms and FBI agents if other, more peaceful options for the House to obtain information from the executive branch are closed off.


The discussion occurred as lawyers for the House and Justice Department sparred over efforts by Democrats to force former White House counsel Don McGahn to testify about his knowledge of alleged wrongdoing by President Donald Trump.


Most of the nine judges who joined in the rare en banc session Tuesday seemed receptive to the House’s concerns, with one judge musing the Trump administration was so intent on sidelining the courts that the public would be left only with "revolution" as an alternative.

A lawyer representing the Trump administration offered a sweeping argument that Congress has no authority to take legal action to enforce its subpoenas because that power lies solely with the president. Rather, lawmakers must rely on a set of political tools — from choking off funding to blocking presidential nominations to impeachment — to bend a stonewalling president to the Congressional will.

“Issuing subpoenas — that's a prerogative of Congress. Enforcing subpoenas and enforcing laws — that’s a prerogative of the president,” Justice Department attorney Hashim Mooppan said.

The House’s top lawyer, Doug Letter, said DOJ’s position would upend decades of practice in congressional investigations and effectively leave lawmakers powerless to stand up to an obstructive administration.

“If the court goes with the Justice Department arguments … congressional oversight as it has been known for this country for years is going to change and be very, very different,” Letter said.

House Democrats are hopeful for a victory from the full appeals court, which is heavy with appointees of President Barack Obama and generally seen as more favorable to the House’s arguments than the three-judge panel which ruled against them 2-1 in February.

Most of the judges taking part in Tuesday’s arguments signaled early and often that they viewed DOJ’s stance with skepticism, repeatedly referencing the extreme notion of the House having to resort to arresting McGahn to get its questions answered or even a judicial resolution of Trump’s claims of executive privilege.

Judge Nina Pillard, an Obama appointee, said DOJ’s stance would leave the House with little but “huge, blunt, disproportionate nuclear options” to try to procure information.

The high-stakes battle over the House’s demand for testimony from McGahn could decide one of the most urgent political issues of Trump’s presidency — whether the White House can block Congress from using the legal system to force crucial witnesses to testify about alleged obstruction of justice by the president himself.

But it also has the potential to reshape the relationship between presidents and Congress for generations to come.

A decision by the courts seems increasingly unlikely to come in any definitive way on a timeline that would produce testimony from McGahn or other witnesses in advance of the November presidential election.

That reality, as some congressional Democrats feared, represents a win for Trump, whom they accused of tying up their case in unending litigation to prevent McGahn from publicly testifying about presidential wrongdoing. McGahn was a central witness in the two-year investigation led by former special counsel Robert Mueller into the Trump campaign’s contacts with Russians in 2016. He ultimately provided damning evidence that Trump repeatedly sought to obstruct the probe, though he declined to recommend criminal charges, citing a Justice Department prohibition on moving against a sitting president.

But even if the D.C. Circuit ultimately orders McGahn to testify, Justice Department lawyers are expected to ask the Supreme Court to step in. The justices may well decide to freeze the status quo, putting potential high court arguments in the case off until the fall or winter and pushing off a final decision until well after Trump is sworn in for a second term as president or Joe Biden is sworn in for a first.
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