Are you LSTing them? That would be the first thing I'd do.
After that, I would FIM your main cola, but you have to be careful doing that and get it in exactly the right spot which is funny because FIM actually means "Fuck, I Missed" in regards to topping
I wouldn't prune your plants leaves unless--and this is not something to do often--the leaves in question are at the bottom, not receiving much light, yellowing/mostly yellow with brown spots and easily detach from the plant without you tugging too hard on the leaf.