When does a plant contain highest levels of CBDA/THCA ?

I am learning about CBDAs ability to inhibit the production of the Cox-2 enzyme in order to relieve inflammation, as well as the benefits of THCA. I want to make a FECO high in CBDA/CBD and THCA/THC. I am trying to find out when the highest levels of CBDA /THCA would be found in a plants flowers. I am currently under the impression that THCA will be highest when the trichomes are clear, so harvesting about day 28-35 seems like it would be the best for peak THCA levels . Is this a telling sign that CBDA is highest as well?

You and everybody else growing weed would love to have some scientific evidence to this answer.

Also every plant is different. Impossible to say....on this day....

Failmore said:

You and everybody else growing weed would love to have some scientific evidence to this answer.

Also every plant is different. Impossible to say....on this day....

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Of course it’s strain dependent that’s why I’m asking for An average. If I can’t find anything I’m just going to do my own research . I don’t believe the lab tests are too expensive. Certainly the tests have been done already, someone out there knows.

PlainfieldPuff said:

I am learning about CBDAs ability to inhibit the production of the Cox-2 enzyme in order to relieve pain, as well as the benefits of THCA. I want to make a FECO high in CBDA/CBD and THCA/THC. I am trying to find out when the highest levels of CBDA /THCA would be found in a plants flowers. I am currently under the impression that THCA will be highest when the trichomes are clear, so harvesting about day 28-35 seems like it would be the best for peak THCA levels . Is this a telling sign that CBDA is highest as well?

1. On average, what day in flower are CBDA levels the highest within the flowers?
2. On average, what day in flower are THCA levels the highest within the flowers?
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Can you post your citations on that? Thank you

PlainfieldPuff said:

Of course it’s strain dependent that’s why I’m asking for An average. If I can’t find anything I’m just going to do my own research . I don’t believe the lab tests are too expensive. Certainly the tests have been done already, someone out there knows.

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I believe he said plant not geno or pheno. I would concur especially when you consider epigenomic triggers.

curious2garden said:

Can you post your citations on that? Thank you

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Found some information actually. Does anyone make any sense of the fact that THCA and CBDA peak at like week 7 (day 150 growing) and then stays basically stable til week 11 (day 179 end of flower phase) ?

PlainfieldPuff said:

Found some information actually.

Figure 2. Evolution of the THCA, CBDA, and CBGA content in leaves and...

Download scientific diagram | Evolution of the THCA, CBDA, and CBGA content in leaves and fl owers during the growth of plants from chemotypes I, II, and III. These values are the averages of all studied plants in each chemotype, with each one measured in triplicate. R.G. refers to the...

www.researchgate.net

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You're going to find the most CBDA in Hemp plants as it is the precursor to CBD. Also its' pain relief effects are related to pain secondary to inflammatory disorders such as Rheumatoid Arthritis.

curious2garden said:

You're going to find the most CBDA in Hemp plants as it is the precursor to CBD. Also its' pain relief effects are related to pain secondary to inflammatory disorders such as Rheumatoid Arthritis.

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Well that’s obvious, but Im not sure when cbda is at its highest level.

PlainfieldPuff said:

Well that’s obvious, but Im not sure when cbda is at its highest level.

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PlainfieldPuff said:

.......snip.......
I am currently under the impression that THCA will be highest when the trichomes are clear, so harvesting about day 28-35 seems like it would be the best for peak THCA levels . Is this a telling sign that CBDA is highest as well?

...snip.....

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From my reading it's fresh plant material not so much harvested prematurely and 28 to 35 days is premature. I'd be curious what you find out and how you intend to study this.

Actually I'm wrong. You found the information and previously posted it

Now you get to replicate their science. Thanks! Great post

Well we know that the natural degradation process is THCA> THC > CBN, and this process of decarboxylation begins as soon as the trichome is exposed to oxygen. Therefore we can infer that the decarboxylation of CBDA also begins as soon as the trichome is exposed to oxygen , meaning it will begin to decarboxylate on the living plant as soon as it appears.

We also know that when a trichome is clear , it has high THCA content. When a trichome is cloudy is has high levels of THC. And when trichomes are amber, they are high in CBN.

From what I gather, this study doesn’t take into account the natural process of decarboxylation when exposed to oxygen. It only takes into account the transition from CBGA > CBDA and the presence of CBD and not the degradation further into CBN. That’s why it seems like the CBDA / THCA peak at week 7 and continue to be stable til the end of the flowering phase. I’m not a scientist by any means and please tell me if I’m wrong, but thats the only way I can make sense of this graph. It is enough though to see that the THCA and CBDA rise and fall coincidentally.

My conclusion is that since CBDA and THCA mature at the same rate within both cannabis plants and cannabis flowers , we can gauge the maturity of the CBDA the same way that we gauge the maturity of THCA , by checking the trichomes. If it’s a strain I know I’ll pull it a few days before I usually see the first cloudy trichome. If it’s a new strain I’ll pull it as soon as I see the first trichome.

Please do not take this as fact, just my personal oppinion based off some quick research. Any and all input is greatly appreciated.

PlainfieldPuff said:

Figure 2. Evolution of the THCA, CBDA, and CBGA content in leaves and...

Download scientific diagram | Evolution of the THCA, CBDA, and CBGA content in leaves and fl owers during the growth of plants from chemotypes I, II, and III. These values are the averages of all studied plants in each chemotype, with each one measured in triplicate. R.G. refers to the...

www.researchgate.net

Well we know that the natural degradation process is THCA> THC > CBN, and this process of decarboxylation begins as soon as the trichome is exposed to oxygen. Therefore we can infer that the decarboxylation of CBDA also begins as soon as the trichome is exposed to oxygen , meaning it will begin to decarboxylate on the living plant as soon as it appears.

We also know that when a trichome is clear , it has high THCA content. When a trichome is cloudy is has high levels of THC. And when trichomes are amber, they are high in CBN.

From what I gather, this study doesn’t take into account the natural process of decarboxylation when exposed to oxygen. It only takes into account the transition from CBGA > CBDA and the presence of CBD and not the degradation further into CBN. That’s why it seems like the CBDA / THCA peak at week 7 and continue to be stable til the end of the flowering phase. I’m not a scientist by any means and please tell me if I’m wrong, but thats the only way I can make sense of this graph. It is enough though to see that the THCA and CBDA rise and fall coincidentally.

My conclusion is that since CBDA and THCA mature at the same rate within both cannabis plants and cannabis flowers , we can gauge the maturity of the CBDA the same way that we gauge the maturity of THCA , by checking the trichomes.

Please do not take this as fact, just my personal oppinion based off some quick research. Any and all input is greatly appreciated.

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Unfortunately I do not come to that same conclusion. It seems a calendar and once you are in the window you begin plant testing. The window depends on if you are focused on leaves or flowers and varies by genotype, then phenotype and husbandry. I think Trichomes are irrelevant.

curious2garden said:

Unfortunately I do not come to that same conclusion. It seems a calendar and once you are in the window you begin plant testing. The window depends on if you are focused on leaves or flowers and varies by genotype, then phenotype and husbandry. I think Trichomes are irrelevant.

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Leaves or flowers doesn’t make a difference since the content of THCA and CBDA rise and fall all the same. Its clear that the peak levels of THCA and CBDA occur during the same days on each sample.

I wouldn’t say trichomes are irrelevant , do you think they are completely and totally irrelevant when choosing when to harvest ? Do you believe they serve no purpose in deciding how much THC is in your trichome with the naked eye, as a quick reference?

PlainfieldPuff said:

Leaves or flowers doesn’t make a difference since the content of THCA and CBDA rise and fall all the same. Its clear that the peak levels of THCA and CBDA occur during the same days on each sample.

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You're not paying attention to the first derivative. Look at that, it tells you the leaves carry less and that you have more time to reach 0, maximum point on your parabola. So that leaves vs flowers are different.

PlainfieldPuff said:

I wouldn’t say trichomes are irrelevant , do you think they are completely and totally irrelevant when choosing when to harvest ? Do you believe they serve no purpose in deciding how much THC is in your trichome with the naked eye, as a quick reference?

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In this instance yes I believe Trichomes are irrelevant as there are no studies that tie color to calendar date and their data is based on calendar. Further measuring clear/cloudy/amber and percent over the plant becomes more and more subjective the more variables you add and the less definition of those variables.

I never looked at trichs because when they get scraped or touched or even slightly damaged they appear amber and “mature”
Even if then plant is at week 3 or 4. I kinda just let the plant look like it’s ready. Usually around 10 weeks for most. Then I start trusting trichome color tad more

PlainfieldPuff said:

I am learning about CBDAs ability to inhibit the production of the Cox-2 enzyme in order to relieve inflammation, as well as the benefits of THCA. I want to make a FECO high in CBDA/CBD and THCA/THC. I am trying to find out when the highest levels of CBDA /THCA would be found in a plants flowers. I am currently under the impression that THCA will be highest when the trichomes are clear, so harvesting about day 28-35 seems like it would be the best for peak THCA levels . Is this a telling sign that CBDA is highest as well?

https://medicinalgenomics.com/wp-content/uploads/2011/12/Drug-Metab-Dispos-2008-Takeda-1917-211.pdf

1. On average, what day in flower are CBDA levels the highest within the flowers?
2. On average, what day in flower are THCA levels the highest within the flowers?
​

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the point where thc etc degrades when the trics fade to gold or tan is the tipping point ..also the best time to harvest

PlainfieldPuff said:

I am learning about CBDAs ability to inhibit the production of the Cox-2 enzyme in order to relieve inflammation, as well as the benefits of THCA. I want to make a FECO high in CBDA/CBD and THCA/THC. I am trying to find out when the highest levels of CBDA /THCA would be found in a plants flowers. I am currently under the impression that THCA will be highest when the trichomes are clear, so harvesting about day 28-35 seems like it would be the best for peak THCA levels . Is this a telling sign that CBDA is highest as well?

https://medicinalgenomics.com/wp-content/uploads/2011/12/Drug-Metab-Dispos-2008-Takeda-1917-211.pdf

1. On average, what day in flower are CBDA levels the highest within the flowers?
2. On average, what day in flower are THCA levels the highest within the flowers?
​

Click to expand...

What is the best way to ingest for CBDA and THCA? Am I understanding correctly this post
https://www.rollitup.org/t/when-does-a-plant-contain-highest-levels-of-cbda-thca.1060088/
where it cites Dussy et al 2005? Isn't it saying smoking only converts 30% of THCA to THC whereas cooking (and I assume decarbing?) converts 70-90%. Therefore if smoking you ingest more "A" than cooking! And if so, if eating would it be better not to decarb to maximize the "A" effect? I don't know FECO, is that decarbed?

Posted this a while ago but it pertains I think.
^^^^that article explains how marijuana uses thc and cbd for senescence

and this is from dr bugbee and his team. it shows peak thc and cbd at weeks 5 and 6 then it drops


the plants builds up high levels of cannabinoids to kill itself