Will You Take The Vaccine?
- Thread starter Unclebaldrick
- Start date
DIY-HP-LED
Well-Known Member
We've stretched out the dosing interval in Canada to stretch limited supplies and cover everybody we can to some degree. I recently got a Moderna as a second and a Pfizer 10 weeks before, so it seems to be working out OK here with over 54% of eligible now with a second dose and almost 80% with the first dose.
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www.business-standard.com
Longer gap in Pfizer-BioNTech Covid vaccine boosts antibody levels: Study
A longer gap between first and second doses of the Pfizer-BioNTech COVID-19 vaccine generates strong antibody and T cell immune responses, UK researchers have found.
A longer gap between first and second doses of the Pfizer-BioNTech COVID-19 vaccine generates strong antibody and T cell immune responses, UK researchers have found.
The study, led by the University of Oxford, in collaboration with the Universities of Birmingham, Newcastle, Liverpool, Sheffield, and supported by the UK Coronavirus Immunology Consortium, is one of the most comprehensive studies into the immune response generated by the Pfizer COVID-19 vaccine to date.
The Protective Immunity from T cells to Covid-19 in Health workers study' (PITCH) found that T cell levels are well-maintained and antibody levels are higher following a longer interval between the first and second dose of the Pfizer COVID-19 vaccine, despite a significant drop in antibody levels between doses.
The studies worldwide are showing that both the short and long dosing schedules lead to strong real-world protection against COVID-19, emphasising the importance of having a second dose of the vaccine.
Our study shows the value of studying both antibody and T cell responses following SARS-CoV-2 vaccine, particularly to understand the multiple mechanisms of protection there may be against new Variants of Concern, said Dr Thushan de Silva, study author and Senior Clinical Lecturer in Infectious Diseases at the University of Sheffield.
The longer dosing interval that the UK has adopted appears to result in higher antibody levels after the second dose when compared to the shorter interval. However, there is a significant drop in antibody levels during this extended interval, while T cell responses are maintained. What is very clear is that two doses are required to maximise protection, particularly against the Delta variant, Silva said.
The study found that overall T cell, a different type of immune cell, levels were 1.6 times lower with a long gap compared with the short dosing schedule of 3-4 weeks, but that a higher proportion were "helper" T cells with the long gap, which support long-term immune memory.
The study of 503 healthcare workers published on Friday found that longer dosing intervals resulted in higher neutralising antibody levels, after the second dose, against the Delta variant and all other Variants of Concern tested.
It found that following two vaccine doses, neutralising antibody levels were twice as high after the longer dosing interval compared with the shorter dosing interval.
Regardless of the dosing schedule, the study found levels of antibodies and T cells varied significantly from person to person, which may depend on genetics, underlying health conditions, and past exposure to COVID-19 and other viruses.
Our study provides reassuring evidence that both dosing schedules generate robust immune responses against SARS-CoV-2 after two doses. For the longer schedule, the antibody levels dropped off between first and second dose, which included the loss of any neutralising effect against the Delta variant," said Dr Rebecca Payne, study author from Newcastle University.
However, T cell responses were consistent, indicating they may contribute to important protection against SARS-CoV-2 during this time, Payne said.
After the second dose on the longer dosing schedule, antibody levels surpassed those seen at the same time point after a shorter dosing interval. Although T cell levels were comparatively lower, the profile of T cells present suggested more support of immune memory and antibody generation. We now need to carry out more follow-up studies to understand the full clinical significance of our findings, Payne said.
This work is the result of a big team effort. The study would not have been possible without collaboration between the researchers across all five universities. It has allowed us to bring clinical cohorts together and conduct one of the most in-depth analyses of the immune response to a COVID-19 vaccine yet, said Professor Susanna Dunachie, PITCH study lead from the University of Oxford.
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Longer gap in Pfizer-BioNTech Covid vaccine boosts antibody levels: Study
A longer gap between first and second doses of the Pfizer-BioNTech COVID-19 vaccine generates strong antibody and T cell immune responses, UK researchers have found.
Longer gap in Pfizer-BioNTech Covid vaccine boosts antibody levels: Study
A longer gap between first and second doses of the Pfizer-BioNTech COVID-19 vaccine generates strong antibody and T cell immune responses, UK researchers have found.
A longer gap between first and second doses of the Pfizer-BioNTech COVID-19 vaccine generates strong antibody and T cell immune responses, UK researchers have found.
The study, led by the University of Oxford, in collaboration with the Universities of Birmingham, Newcastle, Liverpool, Sheffield, and supported by the UK Coronavirus Immunology Consortium, is one of the most comprehensive studies into the immune response generated by the Pfizer COVID-19 vaccine to date.
The Protective Immunity from T cells to Covid-19 in Health workers study' (PITCH) found that T cell levels are well-maintained and antibody levels are higher following a longer interval between the first and second dose of the Pfizer COVID-19 vaccine, despite a significant drop in antibody levels between doses.
The studies worldwide are showing that both the short and long dosing schedules lead to strong real-world protection against COVID-19, emphasising the importance of having a second dose of the vaccine.
Our study shows the value of studying both antibody and T cell responses following SARS-CoV-2 vaccine, particularly to understand the multiple mechanisms of protection there may be against new Variants of Concern, said Dr Thushan de Silva, study author and Senior Clinical Lecturer in Infectious Diseases at the University of Sheffield.
The longer dosing interval that the UK has adopted appears to result in higher antibody levels after the second dose when compared to the shorter interval. However, there is a significant drop in antibody levels during this extended interval, while T cell responses are maintained. What is very clear is that two doses are required to maximise protection, particularly against the Delta variant, Silva said.
The study found that overall T cell, a different type of immune cell, levels were 1.6 times lower with a long gap compared with the short dosing schedule of 3-4 weeks, but that a higher proportion were "helper" T cells with the long gap, which support long-term immune memory.
The study of 503 healthcare workers published on Friday found that longer dosing intervals resulted in higher neutralising antibody levels, after the second dose, against the Delta variant and all other Variants of Concern tested.
It found that following two vaccine doses, neutralising antibody levels were twice as high after the longer dosing interval compared with the shorter dosing interval.
Regardless of the dosing schedule, the study found levels of antibodies and T cells varied significantly from person to person, which may depend on genetics, underlying health conditions, and past exposure to COVID-19 and other viruses.
Our study provides reassuring evidence that both dosing schedules generate robust immune responses against SARS-CoV-2 after two doses. For the longer schedule, the antibody levels dropped off between first and second dose, which included the loss of any neutralising effect against the Delta variant," said Dr Rebecca Payne, study author from Newcastle University.
However, T cell responses were consistent, indicating they may contribute to important protection against SARS-CoV-2 during this time, Payne said.
After the second dose on the longer dosing schedule, antibody levels surpassed those seen at the same time point after a shorter dosing interval. Although T cell levels were comparatively lower, the profile of T cells present suggested more support of immune memory and antibody generation. We now need to carry out more follow-up studies to understand the full clinical significance of our findings, Payne said.
This work is the result of a big team effort. The study would not have been possible without collaboration between the researchers across all five universities. It has allowed us to bring clinical cohorts together and conduct one of the most in-depth analyses of the immune response to a COVID-19 vaccine yet, said Professor Susanna Dunachie, PITCH study lead from the University of Oxford.
DIY-HP-LED
Well-Known Member
Florida COVID-19 hospitalizations jump significantly again
Florida’s COVID-19 hospitalizations again jumped significantly this week as the vaccination rate in rural counties where some of the worst outbreaks are occurring remains well below the state and national average.
Florida COVID-19 hospitalizations jump significantly again
Officials say more than 95% hospitalized not vaccinated
FORT LAUDERDALE, Fla. – Florida’s COVID-19 hospitalizations and cases again jumped significantly this week as the vaccination rate in rural counties where some of the worst outbreaks are occurring remains well below the state and national averages.
About 5,300 Floridians are now hospitalized with COVID, a 65% jump since last week and nearly a tripling since June 14 when 1,845 were hospitalized, the Florida Hospital Association said. Officials have said more than 95% of those hospitalized were not vaccinated.
About 60% of residents 12 and older are vaccinated, according to the state, equal to the national rate. But the percentage of vaccinated adults remains low in the state's rural, strongly conservative north, where some counties are at about 30% as residents don't trust the vaccination program but have high infection rates.
More than 73,000 new coronavirus cases were reported statewide over the past week, according to the state health department, nearly seven times the 12,000 reported a month ago. Florida’s numbers had been falling since mid-January when 100,000 new cases per week were reported and 8,200 were hospitalized just as the vaccination program began.
“This thing got politicized nationally, and we’re paying the price,” said Jared Moskowitz, the state's former emergency management director. “This is mostly now a pandemic amongst the unvaccinated.”
Republican Gov. Ron DeSantis, who has been vaccinated, this week encouraged the remaining unvaccinated Floridians to get their shots.
“If you are vaccinated, fully vaccinated, the chance of you getting seriously ill or dying from COVID is effectively zero,” DeSantis said. “These vaccines are saving lives.”
More than 38,000 Floridians have died with COVID-19 since the pandemic began in March 2020, including an average of 33 per day over the past week. That’s compared with 24 per day earlier this month. In late January, 185 Floridians per day were dying.
Still, despite the recent surge, DeSantis said the state will not return to government mandates — in May, he barred municipalities from imposing their own and banned businesses from requiring proof of vaccination. He said it is up to individuals on how they deal with the pandemic.
“We have a situation where we have three vaccines that have been widely available for months and months now and people need to make decisions that are best for them,” he said. “To have the government come in and to lock anyone down or restrict anyone is totally unacceptable.”
The state's Democrats and their allies said that is the wrong approach and accused him of putting his 2022 reelection campaign and possible 2024 presidential run ahead of Floridians' health. They want cities and counties to be able to again impose their own mandates and restrictions such as requiring masks in indoor public places.
“The surge is ... being facilitated by misguided orders from Tallahassee that block local leaders and businesses from pro-actively protecting individuals from unnecessary exposure,” the 10 Democratic members of Florida’s congressional delegation wrote in a letter to DeSantis.
Florida doctors affiliated with the Committee to Protect Health Care, a progressive group, criticized DeSantis for attacking Dr. Anthony Fauci, the nation’s top government infectious disease official who has pushed for more cautious policies than the governor.
They said DeSantis' recent mocking of Fauci's errant first pitch at a Washington Nationals game a year ago and his reelection campaign's sale of merchandise emblazoned with “Don't Fauci my Florida" detracts from the serious message he should send about the virus. They accused him of dividing Floridians on an issue that should unite them.
“Why is he undermining infectious disease experts and their recommendations? The consequences of (his) leadership has been a steep rise in COVID-19 cases and an increased number of Floridians dying,” said Dr. Frederick Southwick, chief of the University of Florida medical school’s infectious disease division.
DeSantis has argued that his COVID leadership has been effective, protecting nursing home patients, seniors and others of the most vulnerable.
Because of the new outbreak, several hospitals across the state are reinstituting visitation restrictions. Jackson Health, the state’s largest provider, has barred visitors for most of its patients at its hospitals. Others are limiting visitors to one per patient. AdventHealth in central Florida has temporarily stopped doing inpatient elective surgeries.
Jackson said it had 143 COVID-19 patients this week compared with 66 in early July, a 117% increase.
Dr. Lilian Abbo, head of Jackson’s infectious disease prevention program, believes most of those becoming ill are infected with the delta variant as they are becoming sicker faster than with earlier strains of the coronavirus. They are also not seniors and other groups that were previously prevalent.
“We are seeing younger people in their 20s and 30s with not much risk factors -- not obese, not diabetic — coming in very sick,” Abbo said. “Some of them requiring potential lung transplants.”
Budley Doright
Well-Known Member
Honestly not trying to shit on you but IMO this is actually the same problem as the anti-vaccine rhetoric that we all are facing now re covid. I agree that it is your personal choice but to tell people that the vaccine (pox) is the cause and not provide actual proof is irresponsible at the least and possibly dangerous. You “think” you read it somewhere after questioned about the source kind of proves it is most likely bro science. I will do the research (most do but you’ve planted a seed of doubt) and see if the benefits outweigh the side affects. If you do find actual proof then perfect but that proof should have been linked in your first post to add credibility, just my opinion.It might have been at NaturalNews.com where I read about this stuff. I used to be on there a lot until they seemed to go full-bore ReTrumplikan and it got harder to wade thru the rhetoric Mike was spewing
DIY-HP-LED
Well-Known Member
Shingles is common and there is a ton of reliable info out there on it and the vaccine for it, the covid experience has trained many in how to look at such information. While we aren't virologist or epidemiologists, most of us have had quite a lay person's education on the subject. Covid is new and more reliable and detailed information is coming out everyday in the legitimate media now, like what I posted above about intervals between shots. Shingles has been around forever and the vaccines for it have been around for a few years too, so you and your doctor should have all the info you need to make the call.
People passing on anecdotes is an old habit and now that we have the internet we can easily find out the facts (if you have a brain) and provide a link to the source. Though people often ask questions here that they should be typing into google at least!
UncleBuck
Well-Known Member
Has anyone ever told you fuck you?
Budley Doright
Well-Known Member
Well I’m a fact based person and yes I do a lot of research when making a decision, takes me months to buy something (most things) as an example. I think people need to be very careful when stating what sounds like fact but is not. In my field the one big issue is “bro science” when it comes to code compliance, etc. Guys tag (take out of service) equipment based on “I heard that somewhere” false assumptions.
DIY-HP-LED
Well-Known Member
Hey, the AAR field guide (a book of engineering specifications) was my bible for years! I also did time with ISO 9000 and QC, so I hear ya.
It's one of those old habits of passing anecdotes in casual conversation, these days google has saved many hours of bar arguments by providing simple facts to drunks!
captainmorgan
Well-Known Member
DIY-HP-LED
Well-Known Member
More chickens coming home to roost on headstones.
DIY-HP-LED
Well-Known Member
Mask up
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thehill.com
Israel: Pfizer vaccine allows infection but prevents severe illness
A new study released this week from Israel’s Health Ministry found that while the Pfizer-BioNTech vaccine is highly effective at preventing severe COVID-19 cases caused by the delta variant, it was much less effective than the health agency previously thought at protecting people from infection.
The study, conducted from June 20 to July 17, with results released in a report Thursday, found that the two-dose Pfizer-BioNTech inoculation was roughly 88 percent effective at preventing hospitalization due to the delta variant and about 91 percent effective at protecting against severe cases.
However, the Israeli health agency said that for symptomatic COVID-19 cases, the vaccine was found to offer just about 41 percent protection against the delta variant, with an overall effectiveness of 39 percent for preventing delta variant infections.
The new percentage is much lower than the 64 percent effectiveness against delta variant infections that Israel reported earlier this month.
The previous figure drew widespread skepticism from health experts, who argued that mRNA vaccines like the Pfizer shot have repeatedly been shown to offer strong protection against COVID-19 variants.
The initial Israeli report was also challenged by a Public Health England study released Wednesday in the New England Journal of Medicine that found that the two-dose Pfizer vaccine was 88 percent effective against the delta variant.
In comparison, the U.K. health agency said that the AstraZeneca vaccine was 67 percent effective at preventing infection from the delta strain.
Ran Balicer, chairman of Israel’s national expert advisory team on the COVID-19 response, said in a statement along with the Thursday report that their data could have been skewed, citing the ways in which vaccinated groups of people were tested versus those who had not been vaccinated.
“The heavily skewed exposure patterns in the recent outbreak in Israel, which are limited to specific population sectors and localities,” mean that some factors may not be accounted for, he said, according to Bloomberg.
“We are trying to complement this research approach with additional ones, taking additional personal characteristics into account,” Balicer added before noting that “this takes time and larger case numbers.”
...
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Israel: Pfizer vaccine allows infection but prevents severe illness
Vaccine showed just 39 percent effectiveness for preventing delta variant infections.
thehill.com
Israel: Pfizer vaccine allows infection but prevents severe illness
A new study released this week from Israel’s Health Ministry found that while the Pfizer-BioNTech vaccine is highly effective at preventing severe COVID-19 cases caused by the delta variant, it was much less effective than the health agency previously thought at protecting people from infection.
The study, conducted from June 20 to July 17, with results released in a report Thursday, found that the two-dose Pfizer-BioNTech inoculation was roughly 88 percent effective at preventing hospitalization due to the delta variant and about 91 percent effective at protecting against severe cases.
However, the Israeli health agency said that for symptomatic COVID-19 cases, the vaccine was found to offer just about 41 percent protection against the delta variant, with an overall effectiveness of 39 percent for preventing delta variant infections.
The new percentage is much lower than the 64 percent effectiveness against delta variant infections that Israel reported earlier this month.
The previous figure drew widespread skepticism from health experts, who argued that mRNA vaccines like the Pfizer shot have repeatedly been shown to offer strong protection against COVID-19 variants.
The initial Israeli report was also challenged by a Public Health England study released Wednesday in the New England Journal of Medicine that found that the two-dose Pfizer vaccine was 88 percent effective against the delta variant.
In comparison, the U.K. health agency said that the AstraZeneca vaccine was 67 percent effective at preventing infection from the delta strain.
Ran Balicer, chairman of Israel’s national expert advisory team on the COVID-19 response, said in a statement along with the Thursday report that their data could have been skewed, citing the ways in which vaccinated groups of people were tested versus those who had not been vaccinated.
“The heavily skewed exposure patterns in the recent outbreak in Israel, which are limited to specific population sectors and localities,” mean that some factors may not be accounted for, he said, according to Bloomberg.
“We are trying to complement this research approach with additional ones, taking additional personal characteristics into account,” Balicer added before noting that “this takes time and larger case numbers.”
...
Will I am wicked
Member
It's a conspiracy population control there trying to take out the masses
It's funny how many times they have to say this. The extra dumb ones have always just assumed some sort superhero immunity.Mask up
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Israel: Pfizer vaccine allows infection but prevents severe illness
Vaccine showed just 39 percent effectiveness for preventing delta variant infections.
Israel: Pfizer vaccine allows infection but prevents severe illness
A new study released this week from Israel’s Health Ministry found that while the Pfizer-BioNTech vaccine is highly effective at preventing severe COVID-19 cases caused by the delta variant, it was much less effective than the health agency previously thought at protecting people from infection.
The study, conducted from June 20 to July 17, with results released in a report Thursday, found that the two-dose Pfizer-BioNTech inoculation was roughly 88 percent effective at preventing hospitalization due to the delta variant and about 91 percent effective at protecting against severe cases.
However, the Israeli health agency said that for symptomatic COVID-19 cases, the vaccine was found to offer just about 41 percent protection against the delta variant, with an overall effectiveness of 39 percent for preventing delta variant infections.
The new percentage is much lower than the 64 percent effectiveness against delta variant infections that Israel reported earlier this month.
The previous figure drew widespread skepticism from health experts, who argued that mRNA vaccines like the Pfizer shot have repeatedly been shown to offer strong protection against COVID-19 variants.
The initial Israeli report was also challenged by a Public Health England study released Wednesday in the New England Journal of Medicine that found that the two-dose Pfizer vaccine was 88 percent effective against the delta variant.
In comparison, the U.K. health agency said that the AstraZeneca vaccine was 67 percent effective at preventing infection from the delta strain.
Ran Balicer, chairman of Israel’s national expert advisory team on the COVID-19 response, said in a statement along with the Thursday report that their data could have been skewed, citing the ways in which vaccinated groups of people were tested versus those who had not been vaccinated.
“The heavily skewed exposure patterns in the recent outbreak in Israel, which are limited to specific population sectors and localities,” mean that some factors may not be accounted for, he said, according to Bloomberg.
“We are trying to complement this research approach with additional ones, taking additional personal characteristics into account,” Balicer added before noting that “this takes time and larger case numbers.”
...
UncleBuck
Well-Known Member
Your mom took out my mass
CunningCanuk
Well-Known Member
Thoughts and prayers that his suffering ends soon.
this whole deal backfired on them.
Sdh777
Well-Known Member
1. Severe vaccine injuries occur
2. They often go unreported
3. They are often misdiagnosed
4. Most medical facilities do not diagnose or treat vaccine injuries
5. Insurance does not cover most care and treatments for vaccine injury
Although the incidence of vaccine injury is low, it is real and documented with potential neurological adverse events, such as guinn barre syndrome. And if you happen to be one of the unfortunate among the 10’s of thousands of documented cases, good luck getting a proper diagnosis or treatment.
My son was one of the strongest/fastest kids at his school at age 12. During a routine check-up at his PCP, he was given the HPV vaccine, unbeknownst to me. The next day he developed a tic disorder and in the days to follow, he developed cardiogenic syncope, non-epileptic psychogenic seizures, fibromyalgia, autonomic dysfunction, Postural Orthostatic Tachycadia Syndrome, Mast Cell Activation Syndrome and the list goes on. He’s spent the last 3 years nearly bed-ridden, needing a wheelchair or cane to get around.
Due to the litigious & controversial nature of vaccine injury, we were unable to get the proper care for my son as he was repeatedly misdiagnosed and treated with psych meds and therapy instead of the repairing the neurological damage, as well as damage to his immune system and mitochondrion.
My son now has a team of roughly 2 dozen physicians & clinicians, half of which do not accept insurance. We’ve been to dozens of hospitals around the country and I’ve spent over $150k out-of-pocket...and we only saw a worsening of his condition for over 2 years until we finally found the right doctors and began treatment for vaccine injury. We‘ve since managed to reduce most of his symptoms; his seizures are down from nearly 4 hours a day to about an hour a week and his syncopes are down from 12 times a week to near zero, but he may never fully recover and his life has been a living nightmare. His brother had leukemia for 4 1/2 years and that was a walk in the park compared to this.
I’m not saying vaccines, in general, are bad or dangerous; I work in the medical field and get vaccines on an annual basis, but they do come with severe health risks to some, particularly to those with certain genetic susceptibilities. And if you do happen to be one of the unfortunate to become vaccine injured, you are totally screwed...good luck finding proper diagnosis and treatment.
Our team of physicians, including our geneticist, have reached a general consensus that my children are at a heightened risk for neurological and immunological damage and should not receive any further vaccinations.
Do whatever is best for you and your family because most physicians are not properly educated & trained on vaccine injuries and will leave you high and dry when it happens to you. So anyone who would like to vilify us or our children for not having them take the COVID Vaccine can kiss my ass!
2. They often go unreported
3. They are often misdiagnosed
4. Most medical facilities do not diagnose or treat vaccine injuries
5. Insurance does not cover most care and treatments for vaccine injury
Although the incidence of vaccine injury is low, it is real and documented with potential neurological adverse events, such as guinn barre syndrome. And if you happen to be one of the unfortunate among the 10’s of thousands of documented cases, good luck getting a proper diagnosis or treatment.
My son was one of the strongest/fastest kids at his school at age 12. During a routine check-up at his PCP, he was given the HPV vaccine, unbeknownst to me. The next day he developed a tic disorder and in the days to follow, he developed cardiogenic syncope, non-epileptic psychogenic seizures, fibromyalgia, autonomic dysfunction, Postural Orthostatic Tachycadia Syndrome, Mast Cell Activation Syndrome and the list goes on. He’s spent the last 3 years nearly bed-ridden, needing a wheelchair or cane to get around.
Due to the litigious & controversial nature of vaccine injury, we were unable to get the proper care for my son as he was repeatedly misdiagnosed and treated with psych meds and therapy instead of the repairing the neurological damage, as well as damage to his immune system and mitochondrion.
My son now has a team of roughly 2 dozen physicians & clinicians, half of which do not accept insurance. We’ve been to dozens of hospitals around the country and I’ve spent over $150k out-of-pocket...and we only saw a worsening of his condition for over 2 years until we finally found the right doctors and began treatment for vaccine injury. We‘ve since managed to reduce most of his symptoms; his seizures are down from nearly 4 hours a day to about an hour a week and his syncopes are down from 12 times a week to near zero, but he may never fully recover and his life has been a living nightmare. His brother had leukemia for 4 1/2 years and that was a walk in the park compared to this.
I’m not saying vaccines, in general, are bad or dangerous; I work in the medical field and get vaccines on an annual basis, but they do come with severe health risks to some, particularly to those with certain genetic susceptibilities. And if you do happen to be one of the unfortunate to become vaccine injured, you are totally screwed...good luck finding proper diagnosis and treatment.
Our team of physicians, including our geneticist, have reached a general consensus that my children are at a heightened risk for neurological and immunological damage and should not receive any further vaccinations.
Do whatever is best for you and your family because most physicians are not properly educated & trained on vaccine injuries and will leave you high and dry when it happens to you. So anyone who would like to vilify us or our children for not having them take the COVID Vaccine can kiss my ass!
hanimmal
Well-Known Member
I think you are mistaking 'vilifying' a real person with a horrific situation, and calling out death cult trolls for trying to get people to act unsafe.
Dorian2
Well-Known Member
Sorry to hear about your son. Why in the world would they gave an HPV vaccine to him though? Doesn't it have to do with the cervix?
https://www.mayoclinic.org/diseases-conditions/hpv-infection/in-depth/hpv-vaccine/art-20047292