Big difference is a subjective question, it would certainly give you a nice even light spread out across the area. If you got the money I'd say go for it unless you want to get a 1000 watter, the King of Lights..........
I currently have a 400mh over about 15-20 plants and find it a little less that ideal, the spread is smaller than i would like(although its in a deep parabolic reflector, the culprit.), a second one would be a perfect amount of light.